Will Tablets Be Affected By Adjusting The Pre-Compression Pressure Of Tablet Pressing Machine?

1.What Is Tablet Pressing MachineAnd Pre-Compression Pressure Of Tablet Pressing Machine?

AIPAK Tablet Pressing Machine

Tablet pressing machine is the kind of manufacturing machine which make powder and granules into tablets. This machine is mainly applied for the products of pharmaceutical industry. And you can also see its applying in food industry, chemical industry and so on. The high efficiency and great quality of this machine prove your qualified and quick manufacturing.

Tablet pressing machine makes the important pressing job for your tablets products. Pre-compression pressure of tablet pressing machine is the pressing force made before the main compression. It makes the preparing for your tablets pressing work which densify powder and makes the initial shape.

2.Why You Need Pre-Compression Of Tablet Pressing Machine?

Pre-compression of tablet pressing machine makes the important and great work in pharmaceutical industry. Do you know the reason for the irreplaceable place of tablet pressing machine in your pharmaceutical industry?

Uniformity and consistency

Uniformity And Consistency-Sourced:legislativeanalysis

Pre-compression makes sure the uniformity and consistency of your tablets and powder. The removing of void and air pocket make the great preparing for your later tablets manufacturing. Uniformity and consistency make sure the quality of your tablets products and make the tablet products of even feature.

Quality prove

Quality Prove-Sourced:miaspharma

Pre-compresion pressure can also make sure your tablet quality by reducing variability of tablets. The applying of this procedure make the reduction of tablets difference and uniform tablets quality and feature. Your tablets may have the outstanding quality with this step.

Reduce breaking

Reduce Breaking-Sourced:wellrx

Pre-compression pressure can also reduce breaking in tablet pressing work. For the risk of capping or lamination, this step makes the great preparation for tablet manufacturing and improves the completeness and stability of your tablets. The great reduction of breaking is the show of your high manufacturing technique and great tablet quality.

3.Will Tablets Be Affected By Adjusting The Pre-Compression Pressure Of Tablet Pressing Machine?

Will tablets be affected by adjusting the pre-compression pressure of tablet pressing machine? The adjustment of pre-pressing pressure has a significant impact on multiple quality indicators of tablets, such as hardness, friability, appearance, and content uniformity.

Hardness

Hardness-Sourced:prednisonepharmacist

Pressure too low

If the pre-pressing pressure is insufficient, the material will not be compacted properly during the pre-pressing stage. After entering the main compression stage, it becomes difficult to form a dense structure, leading to inadequate tablet hardness. This may result in breakage during subsequent packaging, transportation, and other processes.

Pressure too high

If the pre-pressing pressure is too high, the material may be overly compacted during pre-pressing, reducing the adjustable space in the main compression stage. This could lead to excessively hard tablets, affecting the disintegration and dissolution of the drug within the body.

Friability

Friability-Sourced:malvernpanalytical

Pressure too low

If the internal structure of the tablet is loose and the bonding force between particles is weak, the tablet edges or surface may easily experience powder loss or breakage when subjected to vibration, collision, or other external forces, resulting in unacceptable friability.

Pressure too high

Excessive pressure may cause excessive internal stress in the tablet. During removal from the mold or subsequent storage, the release of this stress could lead to cracks or even breakage, increasing friability.

Appearance

Appearance-Sourced:addictionresource

Pressure too low

Uneven filling of the material may cause the tablet surface to become uneven, leading to defects such as pitting or dimpling, which affect the visual quality of the tablet. The low pressure won’t make the even and complete tablet part and you should adopt the adequate pressure for the great appearance.

Pressure too high

Over-compression in the mold could cause the tablet surface to develop scratches, sticking, or other issues. It may also result in uneven tablet edges, affecting the appearance. Therefor, you should also avoid the adopting of high pressure in making tablets for the nice appearance.

Content Uniformity

Content Uniformity-Sourced:wika

Pressure too low

If the material is not adequately pre-compacted and distributed during the pre-pressing stage, uneven material flow during the main compression stage may result, leading to significant variations in drug content across different parts of the tablet, which affects content uniformity.

Pressure too high

Over-pre-pressing may cause the material particles to break or aggregate, altering the properties and distribution of the material. This can also lead to content uniformity issues and lead the easy breaking of your tablets.

Disintegration Time

Disintegration Time-Sourced:merlin-pc

Pressure too low

With a loose tablet structure, moisture from the disintegration medium can easily penetrate the tablet quickly, causing it to disintegrate too fast and potentially affecting the release and absorption of the drug, hindering its therapeutic effect.

Pressure too high

If the tablet is too compacted, moisture has difficulty penetrating, leading to an extended disintegration time. This may exceed the prescribed disintegration limit, preventing the drug from being released in a timely manner.

4.What Are The Main Parts Of Tablet Pressing Machine?

What are the main parts of tablet pressing machine? Here you may have the basic knowing of automatic tablet pressing machine parts.

Hopper

AIPAK Hopper

Hopper is the place where powder gets into your tablet pressing machine operation work. Hopper has various size and shape, but the different design comes to the same aim of feeding powder or granules into the tablet pressing process. It is the begin of the whole tablet pressing work.

Feeding system

Feeding System-Sourced:piab

Feeding system makes the important work of connecting punch and die system. Feeding housing and feeding peddles make the important tablet pressing machine feeding work. The right and suitable feeding is the base of your great tablets products pressing.

Punch

Punch-Sourced:tablettestingtech

Punch in tablet pressing machine is made with two system and you may find upper punch system and lower punch system which corporate to make the corresponding pressed tablets products. Upper punch system moves vertically and lower punch system stays in the die bore for entire cycle.

Die system

Die System-Sourced:leadtop

The pressing of powder into the die cavity of die system makes the even pressing of tablets. The die cavity of die system decides the tablets basic feature. There are various types of die system for your different tablet product type. You should apply the suitable and clean punch for the manufacturing of the real great tablet molds.

Turret

Turret-Sourced:saintyco

Turret has the full name of rotating turret for tablet pressing machine. Turret makes the house for your die system. Turret affect the production cavity of your tablet pressing machine. With the suitable adjusting of the turret, you may make the efficient and high qualified tablet pressing work in a second.

Ejection cam

Ejection Cam-Sourced:saintytec

After the main compression roller, here is the ejection cam. It makes the important work of ejecting tablets out die cavity. It makes sure the great completeness of your tablets and safe landing of your tablets. For the ejected tablets, it is time for you to collect them for later packing or applying.

5.What Is The Difference Between Pre-Compression System And Dual-Compression Single-Out System?

What is the difference between pre-compression system and dual-compression single-out system?

Pre-Compression System And Dual-Compression Single-Out System-Sourced:tiwin-industry

6.What Are The Common Problem In Tablet Pressing Machine And How To Deal With Them?

There may be some problem in tablet pressing process. The solving of these problem can help you make the better tablets products. Here are the common problem and its relative solution.

Problem-Sourced:americanwatercollege

7.Are There Different Request For Tablet Pressing Machine Of Different Tablet Kind?

Are there different request for tablet pressing machine of different tablet kind? Of course there is. For different tablets, there are different requests.

Effervescent tablets

Effervescent Tablets-Sourced:vitaquest

Effervescent tablets are sleek and sticky. The reliable pressing for this kind of tablets require many preparing works. You should maintain manufacturing temperature in about 17°C and you would better to blow magnesium stearate on mold. The automatic rotating turret can also prevent tablet sticking.

Medicine tablets

Medicine Tablets-Sourced:themedicinemaker

For tablets with pharmaceutical use, there is the strict request on medicine weight. For tablet pressing machine applied for medicine tablets, you should pay more attention on the automation quality inspecting system and pressure inspecting system for the more even tablets products.

8.What Calibration Certificate You Should Have For Your Tablet Pressing Machine Operation?

Here are the calibration certificate you should have for your tablets pressing machine operation and product manufacturing.

IQ

IQ-Sourced:sifo-medical

IQ has the full name of installation qualification which means the formal and documented instruments. It covers the description of item and function of your tablet pressing machine operation. The calibration covers machine connection, pressing work, instrument calibration and so on.

OQ

OQ-Sourced:sifo-medica

OQ refers to operational qualification which makes the comprehensive testing for used and date calibration, test objectives, methods, acceptance criteria and so on. This test can tell you the acceptability and working station of your tablet pressing machine or tablet pressing production line. It is the base of the later smooth pressing work and high qualified tablets production.

9.What You Should Care When Making Pre-Compression?

While making pre-compression, here are the tips you should care for your high qualified tablets products. Have you ever wondered the thing you should care when making pre-compression?

Suitable pre-compression pressure

The pressure strength of tablet pressing machine pre-compression should be adequate. The high strength may lead the breaking of tablets or clapping. And the low strength may fail to make the aimed goal.

Bilayer tablets making

Bilayer Tablets Making-Sourced:promoboz

Pre-compression of tablet pressing machine may lead the lamination in making the bilayer tablet products. And the failing in dealing bilayer tablet products makes it less flexible. And the lamination it lead in making tablet products may also lead some trouble for your products quality.

Products feature affect

Products Feature Affect-Sourced:idntimes

It is known that pre-compression pressure should be one tenth of the main compression pressure. But for different material, there is different pre-compression need for the suitable and reliable pressing. You should adjust the pre-compression strength according to your products feature for the smooth and reliable tablet pressing procedure.

Conclusion

Will tablets be affected by adjusting the pre-compression pressure of tablet pressing machine? Why you need pre-compression of tablet pressing machine? What are the main parts of tablet pressing machine? After the reading of this post, do you want to know more about this machine or any question about pre-compression pressure. Come on and contact AIPAK.