What Is The Difference Between FBP And FBD?
A fluid bed is a core technology best known for its unmatchable outcomes and advantages. There are several types of fluid bed units to offer uniform quality and repeatable products. All of them are employed for drying and cooling and for producing agglomerates and granulates from fine particles.
What is the difference between FBP and FBD? Our review article is specially designed to highlight the distinguishing points between them.
FBP VS FBD
Table of Contents
Ⅰ.Description Of FBP
FBP stands for Fluid Bed Processor that is a versatile technology for making granules from powders using a liquid bridge. This is well-suited technology designed to perform the processes involved:
- Granulation
- Drying
- Coating
Thereby minimizing the number of equipment required for each parameter.
Ⅱ.Description Of FBD
FBD stands for Fluid Bed Dryer that is well known and extensively used equipment in the pharmaceutical granulation area. FBD, as its name suggests is designed to perform the process involved:
- Drying only
It is efficient for industrial application to obtain drying as well as mixing powders.
Ⅲ.When To Use FBP?
Particle Coating: FBP is a commonly used technique for particle coating. Bottom spray fluid bed coating is an excellent method in fluidize the bed coating system.
Pelletizing: FBP mixes and humidifies the powder particle during pelletizing, followed by an addition binding solution or solvent. The continuous centrifugal force produces granules that are spheronized into dense pellets.
Agglomeration:FBP agglomerates or forms granulates from particles; machines dry or cool down the moist granules as well.
Drying: FBP is an efficient means of drying particles. The equipment is capable to evaporate fluid particles from every single solid particle.
Ⅳ.When To Use FBD?
Granulation: FBD is a fast-acting technique; swiftly removes moist particles from powders particles before they go forward to the rotary tablet press machine. FBD is used to make powder particles acceptable for the tableting process.
Ⅴ.How FBP Works?
The working principle of FBP is divided into three sections:
Working Principle Flow Chart of FBP
Fluid Bed Dryer
The principle of a fluid bed dryer is to evaporate excessive moisture out of the particles. The hot air is blown out to pass through them with high pressure via an air distribution plate that lifts the particles from the bottom and keeps them suspended in the air stream.
Fluid Bed Coater
The fluid bed coater is involved with the spraying of granulating or coating solution over the bed of particles respectively. After this process, the coated granules or particles are dried using hot air.
Fluid Bed Granulator
Certainly, there is negligible operational diversity between fluid bed granulators and fluid bed coater. The application of gas is of the same velocities and the spraying area can cover a larger section of the particle bed. This type of machine is meant for the granulation process by suspended particles under fluidized air accompanied by a spraying binding agent from different angles (above, below, or tangentially).
Ⅵ.How FBD Works?
The Process Flow Chart of FBD
Drying
As described above the FBD works following the principle of fluidization where particles are transformed from static to a dynamic fluid-like state. With the help of a perforated air distribution plate; hot air is introduced with high velocity causing them equivalent to gravitational force. This created fluidization where solid particles seem like a boiling bed of liquid. Indeed, each particle gets uniform and efficient drying by this process.
Ⅶ.Process Options: FBP VS FBD
Series | Process | Drying | Granulating | Pellet Coating | Direct Pelletizing | Powder Layering for Pallete |
FBP |
(Top Spray Coater/ Top Spray Granulator) |
|||||
FBP |
Tangential Spray Coater/Tangential Spray Granulator |
|||||
FBD | ||||||
FBP |
Bottom Spray Coater/Bottom Spray Granulator |
|||||
FBP |
Tangential Spray/ Rotor |
The chart above shows process options for FBP VS FBD
Ⅷ.Process Applications Of FBP
Process Applications of FBP
Granulation
- Used to improve the dissolving behavior of particles
- Enhancing compatibility
- Improving product density
- Spherical morphology
Coating
- Used for enteric coating
- Film Coating
- Delayed-Release,
- Hot-melt coating
Drying
- Powder drying
- Reducing the moisture content
- Making particle perfect for tablet press.
Direct Pelletizing
- High bulk density without a starter core
- Formation of pellets
- Improved content of active ingredients
- smooth particle surface.
Ⅸ.Process Applications Of FBD
Used to agglomerate particles.
utilized to dry inorganic substances (fertilizer)
Enhance powder flowability before tablet press
Used to reduce the risk of contamination
Ⅹ.Process Parameters Of FBP
Process Parameter of FBP
Drying
- Temperature:Very high or too low temperature both are undesirable.
- Humidity:The humidity needs to be controlled as much as possible.
- Air Flow: Uniform airflow is critical to achieving proper drying.
Coating
- Spray Nozzle Distance: Efficient coating relies on appropriate distance.
- Droplet Size: For proper coating, droplet size needs to be neither small nor large.
- Spray Rate: The required rate of flow mustnot to be too low or too fast.
- Spray Pressure: For proper atomization, the spray pressure needs to be optimum.
Granulating
- Spray Pressure: This is mandatory to optimize spray pressure for proper solution binding.
- Spray Rate:An optimized spray rate will ensure the successful granulation of particles.
- Nozzle Location: a suitable location ensures better granulation with a binder.
ⅩⅠ.Process Parameters Of FBD
Process Parameter of FBD
Drying
- Position of Air Distribution Plate: It directly influences the airflow pattern inside the machine
- The shape of the Tower: The shape of the tower has a strong impact over-drying rate; an annular shape is preferred.
- Temperature: Increased temperature; increases rate of heat and mass. An optimized temperature must be maintained.
- Air Flux: It must be nottoo fast or too slow.
- Amount of loaded Material: Large batch sizes need moredrying time than smaller batches.
Conclusion
What is the difference between FBP and FBD? The goal of these procedures is to establish a well- controlled setup to produce a quality formulation. The fluidized bed system has extensive pharmaceutical applications to ensure the protection of the drug from external impact with extended shelf life. At Aipak, we design and produce a broad range of fluid bed processors that is up to your customized needs. CONTACT US for more informations and inquiries about these instruments.
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