How Granulator Machine Develops?

Pharmaceuticals is a complex process that needs to go through many procedures, among which granulation is an important part of the pharmaceutical production process.

With the development of the pharmaceutical market, pharmaceutical companies have increasingly higher requirements for granulator machines.

With the rising demand and the continuous improvement of technical requirements, China's granulator technology and process also need to be reformed.

The granulation process is essential in the production of the pharmaceutical industry. The quality of the granulation equipment directly affects the quality of the medicine. In the future development, the pharmaceutical companies will have higher and higher technical requirements for the granulator, and the domestic dry granulator has a long way to go.

The consumption of materials is high, the production cost is high, the intermediate links are many, the process is complicated, the adhesive affects the quality of the finished medicine, and the waste discharge pollutes the environment...

It is reported that the traditional wet granulation technology, while playing a major role in the pharmaceutical field, has many of the above-mentioned defects, which inevitably lead to a series of problems.

In order to avoid these problems, the dry granulator machine has emerged. It is a new granulation method developed after the one-step granulation of the second-generation granulation method. It is an environmentally friendly granulation process, a new equipment that directly compresses medicinal powder into granules.

The Dry granulator machines are widely used for granulation in pharmaceutical, food, chemical and other industries, especially suitable for granulation of materials that are easy to decompose, fail or agglomerate when exposed to moisture and heat. The granules produced by the dry granulator  machine can be directly compressed or filled into capsules.

According to experts, the dry granulator machine uses roll pressure control technology. The control equipment of this equipment can adjust any fluctuation of physical properties between different materials and different batches of the same material so that the process parameters of dry granulation can be adjusted repeatedly.

Thereby, high-quality granules are produced. Dry granulation technology can be completed by a roller flat granulator. The traditional Chinese medicine extract with a certain relative density is spray-dried to obtain dry extract powder.

After adding certain auxiliary materials, it is pressed into flakes by a dry extrusion granulator, and then pulverized into granules. This method requires less excipients, which is beneficial to improving the stability, disintegration and dispersibility of granules.

In the dry granulator machine, all parts that can come into contact with the material are sealed, which can completely avoid the drug quality problem caused by the mixing of lubricating oil and other impurities in the material.

In addition, the bulk density increases substantially after granulation, which greatly reduces dust, reduces material waste, and is more convenient for storage and transportation.

Coupled with low energy consumption and zero discharge of waste, it has greatly reduced the environmental pollution caused by the pharmaceutical industry, and greatly improved its own social image while increasing the economic benefits of the companies.

Granulating is an indispensable part of pharmaceutical industry production, which plays an obvious role.

The quality of granulating equipment directly influences the quality of medicine. In the future development, the pharmaceutical industry will have higher and higher requirements for granulating technology and the cleanliness and functional flexibility will also become the common goal of the industry.

Although dry granulation technology has been significantly developed today, the whole line equipment for pharmaceutical granulation (including three granulation processes: wet granulation, boiling granulation, and dry granulation) is more popular in the market.

The granulation and whole line equipment fully reflects the advantages of the respective equipment of the wet granulator and the boiling drying granulator. At the same time, the combination of the wet granulator and the dry granulator with the system can ensure higher rate of granulation products.

At present, the varieties of dry granulator machines are obviously diversified, and the appearance is also tending to be beautiful, and the overall industry scale continues to expand.

However, it is understood that there are still many "fancy and unusable" devices in the market. Generally, the stability of the device decreases after running for a period of time, mainly due to three major problems.

First of all, the selection of materials and processing technology affect the stability of the dry granulator.

However, there are many equipment rolls are prone to wear and damage after using for a period of time because of the high pressure during the granulating process, which brings inconvenience and loss to companies.

Secondly, many pharmaceutical machine companies design the equipment to be relatively simple and do not consider the problem of dust particles.

Many domestic pharmaceutical factories use dry granulators to produce traditional Chinese medicine granules. Because traditional Chinese medicine granules are easy to absorb moisture and stick, the materials are easy to dry on the dry granulator.

The accumulation blocks the channel, causing pollution of the production environment, affecting the safety of medicines, and the cleaning of equipment has become very cumbersome.

In addition, the industry professionals have reported that after many rollers are used, the pellets formed by pressing the material into flakes contain more fine powder, and the yield of one-time finished products is low.

Some pharmaceutical companies try to compress the screened back powder into tablets and then granulate it. Although this method improves the yield to a certain extent, the dissolution rate and disintegration degree of the granules made by back-pressing are obviously inferior to those of the granules that are pressed at one time, which reduces the quality of the medicine.

Equipment and medicine are complementary roles. The equipment needs to be updated from the production specifications and concepts of medicines, and the structure needs to be adjusted to fully consider the problems that are easy to occur during the production of medicines to ensure the safety of medicines.

With the improvement of GMP requirements, pharmaceutical equipment must keep pace with the times to meet the requirements of the pharmaceutical industry.

Dry granulator machine equipment companies should adhere to the people-oriented concept, make more efforts in design details, and solve equipment defects from the source, so as to ensure the accuracy of equipment and assist the stable development of the pharmaceutical industry.