How About The Materials Used In Tablet Production

1.What Are Tablet Production?

Tablet Production-Sourced:thomasprocessing

Tablet production refers to the compression of pharmaceutical granules or powder excipients into tablet shape. Different models have different sizes and shapes of tablets. There are round, heart-shaped, oval and other shapes and sizes of tablets on the market.

Tablets are popular in the market because of their small size, convenient taking and fast disintegration. There are a variety of drugs suitable for tablet production. Different types of tablets have different compression methods.

2.What Are The Material Used For Tablet Production?

What are the material used for tablet production. For different tablet type, the material is different. And here are the main material used for tablet production.

API

API-Sourced:skyone

API determines the effectiveness of the drug. And different pills have different API for different diseases. For example, vitamins are the main API in dietary supplement tablets. API dosage must be precise. Only in this way can it play a truly effective role for the various disease.

Fillers

Fillers are another major ingredient in drug production. Common fillers include lactose, sucrose, glucose, calcium carbonate, etc. In addition to acting as a filling material, fillers are added to the tablet to help stabilize the product.

Binders

Binders-Sourced:pharmaexcipients

Binders have also a variety of forms. You can find powder-like binders and liquid-like binders. Common adhesives are sucrose, starch, cellulose, gelatin, and so on. The suitable binder makes your strong and stable tablets.

Disintegrants

Disintegrant-Sourced:pharmaexcipients

The disintegrant promotes the disintegration of the tablet into various small fragments after contact with the liquid, which is convenient for the human body to absorb. The disintegrant promotes disintegration and accelerates dissolution of the drug.

3.What Is The Process Of Tablet Production?

Tablet production should be precise and careful. Here are the tablet production process for most tablet manufacturing.

Material preparing

Material Preparing-Sourced:products

For the original raw material, the basic particle grinding and essence extraction should be carried out. High quality raw materials can make higher quality tablets. You should thus prove the high quality of material.

Granulation

Granulation-Sourced:medicalexpo

The basic ingredients of the tablet are various granulates. The improvement of the shape and quality of the granules can improve your tablets quality. You can also adjust the viscosity and fluidity of the granules. Common granulation methods include wet granulation and dry granulation.

Wet granulation is more suitable for granular materials with poor flow and great compaction. Dry granulation is more suitable for materials that are insoluble in water or sensitive to moisture

Material mixing

An even and consistent mix helps to improve the quality of the tablets. Blenders are efficient and can help you save time in a big way. You should make the total mixing for your materials.

Tablet pressing

Tablet Pressing-Sourced:saintyco

After all the materials have been prepared, tablets can be pressed and suitable molds and machines can be selected according to the size and shape of tablets. Tablet pressing can also be customized according to the nature of the tablet or medicine.

Coating

The coating can obstruct the bitter taste of the tablet as well as other unpleasant tastes. It produces a smooth appearance which improves the shape of tablets. It is very effective for many children and the elderly who have difficulty in tablet swallowing.

Packing

Packing-Sourced:types

Beautiful and reliable drug packaging give users the great impression. It can also ensure the safety of drugs in the transportation, storing and so on. You may find blister packing and bottle packing the common packing of tablets.

4.How Will You Benefit From Tablet Production?

Tablet production is efficient and hygienic. It will benefit you in a comprehensive way.

Accurate dosage

Accurate Dosage-Sourced:psu

Tablet production can make the accurate dosage for the small tablets. The little variation of medicine dosage may make the great difference for the various disease handling. The tablet production can have the accurate dosage which will benefit customers in a comprehensive way.

Bioavailability

Tablets have the better dissolution and bioavailability. The great features of tablets can then better serve patients and make the better work of the different kind of API. The high bioavailability of tablet production can thus benefit patients in a comprehensive way.

Stable quality

Tablet production is stable in its quality. The dry solid can be conserved for a longer time. For better and more reliable containing, you may apply coating for tablets for the protection to light, moisture and other invention. For other medicine production, the extra protection is rare.

Convenient for taking

Convenient For Taking-Sourced:thehill

Tablet production makes a lot work for the convenience for patients taking. The small size and sleek structure makes benefits for children and elders. And with the help of coating, tablet production will become more convenient for medicine taking for more people.

5.What Are The Equipment Used For Tablet Production?

Weighing Machine

Weighing Machine-Sourced:precisa

Weighing machines can help accurately measure drug ingredients as well as their weight. The size and weight of the ingredients of the drug are crucial to the qualified production of the drug

Granulator machine

AIPAK Granulator Machine

There are a variety of granulator machine on the market for wet as well as dry granulation production. Fluidized bed dryer is an advanced intelligent granulator machine, which can improve the fluidity of granular powder. It improves the quality of granular powder and can also carry out coating work.

Bin mixer

AIPAK Bin Mixer

The mixing machine is used to mix all kinds of powder ingredients, and the uniform mixing is beneficial to the guarantee of product quality. You may apply bin mixer for the great helper of mixing work.

Tablet pressing machine

AIPAK Tablet Pressing Machine

Tablet pressing is the most important part in the process of making tablets. According to the size, specification, weight and other parameters of the tablet products, the tablet pressing machine presses the drug powder into uniform and beautiful tablets. The tablet press can ensure efficient, safe and hygienic tablet production.

Coating machine

AIPAK Coating Machine

The coating agent is a tablet and is coated with a uniform and beautiful protective layer. The applting of coating machine improve products appearance. It can lead the more attractive and more stable, durable tablets products.

Blister packing machine

AIPAK Blister Packing Machine

Blister packs are a common form of tablet packaging. The blister packaging machine works quickly and hygienically, giving the tablets good protection. Blister packaging is a common form of packaging in the market.

6.What Are The Common Problems In Tablet Production?

There may exist various problem in tablet production. And here are the common problem which you should pay attention to.

Capping

Capping-Sourced:freemantech

Capping refers to the cracks on the surface of the tablet, which will reduce the stability of the drug and make the tablet look less attractive. The reduction in the moisture content of the powder or high compression force can result in air drying. In order to avoid the occurrence of covering, it is necessary to adjust the water content and ensure the compression force

Breakage

Breakage-Sourced:colorcon

Tablet breakage is also a common trouble in tablet making. Small fragments on the edge or surface of the tablet can make the tablet look ugly and affect its dissolving. For this reason, you should optimize the coating process, reduce wear and tear. For customer, you should store the tablets carefully.

Powder sticking

Powder Sticking-Sourced:huadapharma

The presence of powder on the tablet affects the quality and appearance of the tablet. To avoid this, you should ensure that the suitable mold, uniform lubricant, appropriate moisture and uniform particles.

7.What Are The Interactions Among Excipients In Tablet Production?

The excipients in tablet production may make lot affect for tablets products. What are the interactions among excipients in tablet production?

Disintegrants and binders

Disintegrants And Binders-Sourced:mcepharma

Impact on disintegration performance

Binders bind particles together. If they are used in excessive amounts or are not properly matched with disintegrants, they will hinder the disintegration of tablets. For example, when a large amount of starch slurry is used as a binder and insufficient amount of sodium carboxymethyl starch (disintegrant) is added, the tablet disintegration time will be prolonged. This is because the strong binding force formed by excessive binders will offset the effect of disintegrants absorbing water and swelling to disintegrate tablets.

Impact on compressibility

To a certain extent, disintegrants and binders will also affect the compressibility of particles. If the disintegrant has a certain plasticity, it will assist the particle forming during the tableting process; and the viscosity of the binder helps the particles maintain their shape under pressure. The synergistic effect of the two can optimize the compressibility of the particles. However, if the ratio of the two is unbalanced, such as too little binder and too much disintegrant, it will make it difficult for the particles to form during the tableting process, resulting in cracking.

Lubricants and other excipients

Lubricants And Other Excipients-Sourced:philippe-tschopp

Effects with binders

Lubricants may affect the bonding effect of binders. For example, magnesium stearate is a commonly used lubricant. When it is used in large amounts, a hydrophobic layer will form on the surface of the particles, weakening the bonding effect of the binder on the particles, which may lead to a decrease in the hardness of the tablet.

Effects on disintegrants

Some lubricants may interfere with the effect of disintegrants. For example, when there is too much magnesium stearate, a hydrophobic film will form around the tablet, preventing water from entering the tablet. It is difficult for the disintegrant to absorb water and swell which prolongs the disintegration time.

Between fillers

Between Fillers-Sourced:freund

Effect of density differences

Different fillers have different densities, and stratification may occur during mixing. For example, when light magnesium oxide and lactose are mixed, if the mixing is not sufficient, the distribution of ingredients may be uneven during transportation or storage, which in turn affects the tablet weight difference and content uniformity of the tablet.

Synergistic effect on drug release

Certain filler combinations can regulate drug release. For example, when microcrystalline cellulose and lactose are used together as fillers, microcrystalline cellulose can improve compressibility and lactose can regulate the dissolution rate of the drug. The combination of the two can make the release of the drug in the body more in line with expectations.

8.How Does Material Affect Uniformity Of Tablet Production?

The different material can also affect tablet production? How does material affect its uniformity?

Quality

Quality-Sourced:technologynetworks

Content uniformity

If the mixing is not uniform, the content of active ingredients in the tablets will be inconsistent. For example, when producing tablets containing drugs, the drug ingredients are unevenly distributed, and some tablets may contain drug content that exceeds the specified range, while others are below the effective dose which will affect the efficacy of the drug.

Weight variation

Uneven mixing may cause large differences in weight between different tablets. Because the bulk density and other properties of the materials may be different, poor mixing will cause different filling conditions of the ingredients in the tableting mold, resulting in tablet weight fluctuations.

Production process

Production Process-Sourced:istockphoto

Flow

Good mixing uniformity can make the material have better flow. Evenly mixed materials are smoother during the conveying process to the tablet press, which can ensure a stable feeding rate. Uneven materials may have stratification, agglomeration, etc., which will make the material flow worse, thereby affecting the continuity and efficiency of tablet production.

Compress

Mixing uniformity affects the compressing of the material. When the materials are mixed evenly, the various ingredients can be evenly distributed in the tablet and can be better combined during the tablet production process. If the mixing is not uniform, it may cause uneven local pressure distribution, causing tablets to crack or loosen.

Stability and appearance

Stability And Appearance-Sourced:sciencepharma

Stability

Evenly mixed materials help improve the stability of tablets. For example, for some hygroscopic or oxidizable ingredients, only when they are evenly distributed inside the tablet can they be better protected by other ingredients, preventing local moisture absorption or oxidation and extending the shelf life of the tablets.

Appearance

Tablets pressed from materials with high uniformity have more uniform color and appearance. If the mixing is not good, spots and uneven color may occur, affecting the appearance quality of the tablets.

9.What Are The Features Of The Qualified Tablet?

For the high qualified tablets, here are the features you should check. The high qualified tablets can give the best effect.

Uniform and even

The qualified tablets should be uniform and even. These are the basic features of the qualified tables. The two features can prove the efficiency and raw material quality of your products.

Stable

Stable-Sourced:telugutimes

The high qualified tablets should be stable in their effect and shelf life. The variants shelf life lead the problem for many patients. You should choose the stable tablets for your use.

Effective and safe

The tablets should be effective and safe. You should make clear the effect, decomposition time, safety and so on for your tablets taking. The basic features are the most important features for you.

Good looking

Good Looking-Sourced:etsy

The qualified tablets should be smooth and sleek in its appearance. The parts lack, discoloration and many problem in its appearance show the low quality of the tables. Besides, beautiful tablets are also more attractive.

Conclusion

How about the materials used in tablet production? How much you know about tablets production? Do you know the selection and production of tablets? Tablets benefit many of us and are welcomed in many market. And for any question or problem, you may have no hesitate to contact us now.