How To Solve Common Problems Of Dry Granulator Machine

The dry granulator machine is a machine that uses the swinging action of a rotating drum to grind wet powder raw materials into granules through a wire sieve. It is currently widely used in pharmaceutical and other industries.

According to different uses, dry granulator machine can be divided into production type and experimental type. Among them, the experimental dry granulator machine is mainly used for the development and research of new dosage forms in the Institute of Medicine and the production of small-dose traditional Chinese medicine preparations.

At present, some equipment on the market can realize clean and closed production from powder to granules, and the human-machine interface is safe. , reliable, fast, and a large amount of information, the yield of particles is high. At the same time, the design of the transparent working area makes the observation more direct and convenient.

Currently, some domestic dry granulator manufacturers have developed a new type of dry granulator based on imported models and combined with their own national conditions, which are suitable for the production of various materials, and the system provides a wide range of equipment, processes and operators.

Advanced password management control is convenient for the safe operation of equipment, production management and product quality control.

No matter what type of dry granulator machine it is, you inevitably need to face the occurrence of some common troubles in the process of use, find out the problems in time and deal with them accordingly.

Among them, the large amount of dust is a problem that many of you have deeply experienced. So why does this happen? Some technical manufacturers have made a brief analysis on this.

First, the problem of equipment structure design. It is understood that due to many dry granulator manufacturers design the equipment to be relatively simple and do not consider the problem of dust particles, the dust production of the equipment is very large, which has an impact on the production of users.

With the improvement of GMP requirements and the introduction of the cGMP concept, dry granulator manufacturers also need to update the specifications and concepts of drug production.

Adjust the structure, and fully consider the dust particles generated during drug production to ensure the production environment, in order to meet the requirements of high-quality development of the pharmaceutical industry.

The technician also reminded that another thing to pay attention to about the dust generation problem is the vibration of the equipment.

Vibration will increase the generation of dust particles and increase the spread of dust particles, so when manufacturing equipment, it is necessary to consider the overall structure and manufacturing accuracy to find the vibration source that causes vibration, so as to reduce the vibration generated by the equipment.

Second, the degassing effect is not good. It is understood that after the air in the particle gap is

compressed, when the granulation is broken, the pressure is suddenly released, and the gas explosion causes a large amount of fine powder, so the dust production is large.

Third,Particles are too hard. The industrial said that when encountering the problem of too hard particles, it should be noted that if the pressure of the pressing roller is too high during the dry granulation process, the pressed dry particles will be too hard. , resulting in a large pressure to be pressed to form the tablet, and the machine vibrates greatly.

In the case of capsules, because the dry particles are too hard, the compressibility is lost may result in the material being thrown away during the filling process of the capsule because the grain cannot be used, resulting in a far greater difference in filling volume.

Fourth, the uniformity of particle size. In order to deal with the problem of uniform particle distribution during tabletting, several aspects need to be considered: ensure uniform mixing under high-speed stirring; control the fine powder below 80 mesh within a certain limitation.

During tabletting, you need to use forced feeding device to prevent delamination. If the above aspects are considered reasonably, the uniformity of the product can be well controlled.

Third, the roll problem. There is cooling water inside the roll, and there are dynamic sealing devices on the rotating roll and the static cooling water pipeline, but there will be leakage problems under high pressure after a long time of use.

At present, some manufacturers have improved the structure of the roll so that the cooling water directly leads to the surface of the pressure roller, which can effectively reduce the surface temperature of the roll and reduce the possibility of leakage.

It is an improvement. Due to the material selection and processing technology, many rolls are subject to wear and damage after a period of use due to the high pressure during granulation, so many manufacturers use it for a period of time. To repurchase rolls.

The market prospect of granular drugs is huge, and the market demand for dry granulator equipment will also usher in growth. In this context, dry granulator manufacturers also need to improve the process and structural design to continuously meet the needs of users for granulation.

Judging from the current development of the tablet industry, the frequent introduction of policies in the pharmaceutical field and the continuous growth of market demand, the tablet industry is facing a new round of structural adjustment while ushering in great development prospects.

The technology of granulation and mixing equipment. It is also in urgent need of upgrading, and products are in urgent need of upgrading. In this update, how to make breakthroughs in the domestic granulating mixer equipment industry is the key to challenging foreign imported equipment.

According to the professional, our domestic granulation equipment needs to develop companies and enhance competitiveness with a pragmatic attitude through independent innovation and in-depth digestion.

Relevant companies must build mixing and granulating equipment suitable for the needs of the domestic pharmaceutical industry with strong scientific research strength and innovative spirit, constantly catch up with foreign advanced pharmaceutical machinery technology, and open up new ground for my country's pharmaceutical equipment industry.