5 Points You Must Know About The Suppository Filling Machine

The high output suppository filling machine has stable and efficient preheating moulds, heating moulds, forming moulds, banding, filling, freezing and sealing processes to complete the entire process of suppository production, with a production capacity of 18,000-23,000 capsules per hour.

As an indispensable hardware condition for the implementation of GMP and the guarantee of drug quality in the production process, high output suppository filling machine is gaining more and more attention and concern from pharmaceutical companies.

Here you will several summaries of the suppository filling machine required for each process index unit of oral solid dosage formulations, and analysis of the structure and principle of the equipment, and summarise its characteristics and scope of use, in order to optimise the process route through the equipment parameters, so that it can play a better role in the development of formulations.

The process of breaking large particles into smaller ones by overcoming the cohesion of the solid material under the action of an external force is called crushing.

The purpose of crushing: to reduce the particle size and to improve the homogeneity of the mixture between the materials. The crushing operation is an important part of the raw material processing and post-processing technology of the drug. The crushing technology is directly related to the quality and application performance of the product.

If the ball jar slowly rotates, the layers of grinding balls have relative movement, known as slippage.

The increase in speed of the ball jar, the surface layer of the ball along the outer layer of the ball down the diarrhoea, diarrhoea when the crushing of the material is mainly grinding effect.

After the increase in speed, part of the grinding ball with the tank rose to a higher height, and then along the parabolic throw down, when the crushing of materials is the combined effect of impact and grinding.

The development of foreign preparation equipment is characterised by closed production, multi-functional, continuous, automated, with the gradual development of domestic preparation process and the increase in the number of varieties of dosage forms, China's preparation equipment is also increasingly close to the international level of development, more and more equipment and the introduction of more relevant advanced technology, which is transformed into productivity, making the whole pharmaceutical field to improve the overall level.

Then after getting to know some trends of the suppository filling machine,you should know several points regarding problems during the production:

How to deal with thewater droplets and air bubbles during the production of automatic suppository filling machine?

The filling accuracy of the automatic suppository filling machine is the primary factor to measure the performance of the small filling machine, which directly affects the quality of drugs, the stability of the filling accuracy is an important guarantee for the production of qualified drugs.

For ceramic pump filling system instability, from the mechanical structure and electrical control of the two aspects of the causes of its analysis, and proposed a solution.

Filling is carried out by means of absolute position control of the servo motor, which allows precise positioning.

When the servo motor does not reach the position, the servo motor will alarm and stop the filling and equipment; at the same time, the control of the rotary valve is the same as the control of the filling pump; there is also the control of the needle frame reciprocation and lifting, the above three points belong to electrical control.

Measures to deal with water droplets and bubbles generated by the products of automatic suppository filling machine are below:

The connection between the silicone tube and the liquid separator and ceramic pump will also produce bubbles or droplets if it is not tightened.

Solution: Add a non-return valve before each start-up and replace the connector or silicone tube immediately if any of the above occurs.

Do not use non-metallic materials for the steriliser. When sterilising, the extractor rod comes into contact with metal materials. The combination of the extractor rod and metal materials will easily lead to wear and tear of the extractor rod, poor air tightness and bubbles during filling.

Solution: Try to choose special sterilisation equipment.

When installing the pump, the pump body and the pumping rod appear to be mixed loads and the pump gap is not matched, which easily leads to wear of the pumping rod, poor air tightness and bubbles during filling.

Solution: pump body and pumping rod label, do not mix.

The installation position of the liquid storage tank, liquid separator, ceramic pump and needle holder, the height difference between the buffer tank and the ceramic pump installation position is too large, the pressure of the ceramic pump is too large, which will easily lead to pinning.

Solution: Minimise the height difference between the installation positions of the components, otherwise, add another buffer device between the buffer tank and the pump.

Is it difficult to control the program of the automatic suppository filling machine?

The automatic suppository filling machine has a stable and efficient production process of pre-heating mould, heating mould, forming mould, belt making, filling, freezing and sealing to complete the whole process of suppository making, with a production capacity of 5,000-6,000 capsules/hour.

The conveyor belt of the whole line is made of POM steel, which is wear-resistant and corrosion-resistant, low noise and easy to clean. The pneumatic components of the whole line are JYC, which are of reliable quality.

Guardrails, sensors, filling nozzles, positioning cylinders, all can be easily adjusted in position to suit various sizes of containers. The filling machine adopts self-flowing insertion filling, which reduces foam and does not spill when filling.

The machine adopts Taiwan Wellenton 5.7" colour man-machine interface, reflecting the human-centred theory, with relevant buttons to display the program and sensor actuators. 4 heads are dispatched independently, and there are alarm functions for lack of material and touching nozzles.

The filling production line uses a computer to precisely control and adjust various parameters, with parameter storage and replacement functions.

The working principle of the suppository filling machine 

Colour-coded positioning and photoelectric tracking: In order to ensure the integrity of the trademark pattern on the finished packaging bag, a colour-coded label for positioning is usually printed on the packaging material when it is made.

When using such packaging materials printed with colour coding, photoelectric switches (electric eyes) can be used to track the positioning of the colour coding, through the control system to drive the stepper motor rotation and automatic stop according to the distance between the colour coding, to achieve complete and accurate packaging finished trademark pattern and plastic hose, filling valve using 3.4 # stainless steel materials, corrosion-resistant and easy to clean and disinfect, in line with national requirements on food machinery, food hygiene and.

Features of the suppository filling machine

Filling production line adopts human-machine interface, the program control is convenient, reliable, easy and convenient to operate.

The whole line adopts infrared sensor, the position control is more accurate. The whole line adopts domestic electrical parts for electrical switches. The whole line adopts high quality mechanical speed control motor for the conveying motor and high quality non-suspension pneumatic control valve for the filling production line, which can be controlled quickly and reliably.

Besides,suppository filling machine has stable preheating mould, heating mould, forming mould, belt making, filling, freezing, sealing and other production processes to complete the entire process of suppository making, production capacity of 5,000-6,000 particles / hour.

The filling barrel is equipped with an electric heating and insulation system and a stirring motor at the top to keep the drug in a homogeneous state. The drug in the barrel enters the filling head via a high precision filling pump and the remaining drug after one filling is circulated through the other end to the raw material barrel for the next filling.

4 Reasons why suppository filling machine sealing well

Firstly,it maybe the heat sealing film quality is not qualified,if the composite lining material corona treatment is not uniform, the effect is not good, and happens to appear in the seal, certainly can not seal.

This situation is rare, however, once it occurs, the product is bound to be scrapped. So in the color printing and packaging industry, is the next process to supervise the upper process, a found quality problems, to analyze the cause and to solve.

Secondly,the filling machine heat sealing speed is too fast. If the speed is too fast, the seal has not yet had time to heat up the traction roller transfer to the cold press for cooling processing, naturally can not meet the quality requirements of heat sealing.

Thirdly,the filling machine heat sealing temperature is not enough, usually, when the total thickness of the bag-making 80 ~ 90μm, heat sealing temperature to reach 170 ~ 180 ℃; composite bag-making total thickness of 85 ~ 100μm, the temperature should be controlled at 180 ~ 200 ℃.

As long as the total thickness of the bag-making increases, the heat sealing temperature should be increased accordingly.

Forthly,the filling machine's cold pressure rubber wheel pressure is not appropriate, there is cold pressure on each up and down rubber wheel.The pressure between them need to be adjusted to moderate,so you need to adjust the clamping spring

Effective pollution control during the production of suppository filling machine

The suppository filling machine has an embedded filling system for filling the suppositories at once, with a filling accuracy of ± 2%.

The filling drum is equipped with an electric heating and insulation system and a stirring motor at the top to keep the drug in a homogeneous state.

Suppository filling machine requires effective contamination control during the production process to reduce the risk of non-compliance and to reduce downtime.

Most biological preparations are made by microbial fermentation or mammalian cell culture. Microbial contamination can affect the robustness and reproducibility of the biomanufacturing process, as well as the purity, efficacy and safety of the final drug product.

This therefore places greater demands on biopharmaceutical companies as well as pharmaceutical equipment suppliers.

As the competition in the drug market becomes increasingly fierce, and as market regulations on drug safety become more stringent, many biopharmaceutical companies are increasingly demanding intelligent, automated and digitalised processes.

Automated production processes offer the advantage of more robust production and greater flexibility than traditional production models. As a result, peristaltic pumps have become the preferred choice for most biologics filling processes in aseptic filling operation units.